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A 2023 analysis of real-world tirzepatide prescribing patterns (Blonde et al., Diabetes Obesity and Metabolism 2023) found that patients on extended titration schedules (6 to 8 weeks per dose level instead of 4 weeks) had 40% lower discontinuation rates due to adverse events, with no significant difference in weight loss at 12 months

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However, rapid weight loss can shift thyroid hormone metabolism and metabolism rate, potentially requiring levothyroxine dose adjustments

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