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Genetic variants in GLP1R (e.g., rs6923761) and GIPR (e.g., rs1800437) are associated with variation in appetite regulation and glucose metabolism
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In diet-induced obese mice, chronic Retatrutide dosing produced greater reductions in adipose mass and food intake than matched-exposure Semaglutide or Tirzepatide comparators, with indirect calorimetry showing increased energy expenditure attributable to the GCGR component and reduced hepatic triglyceride content on histology
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