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We further removed the GSA linker residues and found that a single GSA with two additional EF residues from the Eco RI cloning site is sufficient to activate the C347K mutant receptor at 30% of the activity of full-length peptide fusion receptor (Figure 5c, expression levels shown in Supplementary Figure S2A)
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The combination of metformin and GLP-1 receptor agonists has shown promise in managing PCOS, leveraging the complementary effects of both medications
