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๐ How much can each antidiabetic drug drop HbA1C? ๐ฉธ โก Sulfonylurea: 1โ2% โก GLP-1 agonist: 0.5โ1.1% โก SGLT-2 inhibitor: 0.8โ0.9% โก Metformin: ~1% โก Glitazone: 1โ1.5% โก Insulin: ๐ฅ up to
The most recent understanding of this deficit suggests that it relates to deterioration of the GLP-1 effect, with impaired capacity to secrete insulin, increasing insulin resistance, and hyperglycemia, perhaps leading to a decrease in GLP-1 receptor expression and resulting in GLP-1 resistance (7)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.McIntyre R.S., Mansur R.B., Rosenblat J.D., Rhee T.G., Cao B., Teopiz K.M., Wong S., Le G.H., Ho R., Kwan A.T.H