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When GLP-1 binds to GLP-1R on the surface of β-cells, cAMP-dependent PKA is activated and subsequently activates the downstream signal PI3K, which inhibits apoptosis in islet β-cells by blocking the expression of the pro-apoptotic protein Bax (Li et al., 2021) (Figure 4)

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5 (2016): 907–917, 10.1007/s00125-016-3899-2