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This drug may also cause side effects nausea/vomiting, diarrhea, abdominal pain, and constipation
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however, GLIM does not exert this effect and preserves myocardial ischemic preconditioning.[5] Moreover, a lesser pancreatic overstimulation and resultant low hypoglycemia by GLIC could be due to the restoration of the early insulin peak in response to glucose stimulation and higher reversibility of binding of GLIC to the SUR1 of β-cell.[36] In addition, modern SUs also exhibit certain pleiotropic effects such as insulin clearance, glucagon secretion, insulin sensitization, anti-oxidative effect, angiogenesis, vascular health, and ischemic preconditioning.[5] Summary of guidelines recommending SUs and combinations for the management of type 2 diabetes mellitus The addition of SUs has been the gold standard combination therapy for decades in patients who fail to achieve target glycemic control with metformin monotherapy.[37] In addition, pertaining to their low cost and high efficacy, SUs are widely used as a second-line agent in different regions of the world for the management of diabetes
