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Last year, FDA—acting through the Office of Prescription Drug Promotion (“OPDP”) within the Center for Drug Evaluation and Research (“CDER”)—issued a high volume of untitled and warning letters as part of a broader push against direct‑to‑consumer (“DTC”) drug advertising, including 58 letters addressing claims about compounded GLP‑1s (e.g., semaglutide and tirzepatide) and other compounded products (e.g., sildenafil and tadalafil).[2] By mid‑2026, activity appeared to taper off—raising the question whether FDA had shifted priorities, for example due to personnel changes, or simply paused the effort

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While lifestyle changes remain essential, they are often not sufficient