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Retatrutide (also known as LY3437943) is an investigational medication developed by Eli Lilly that activates three key metabolic receptors : GLP-1 (glucagon-like peptide-1): reduces appetite and improves blood sugar control GIP (glucose-dependent insulinotropic polypeptide): enhances insulin response Glucagon receptor: increases energy expenditure and fat metabolism This “triple-hormone weight loss drug” approach creates a balanced effect, suppressing hunger and increasing calorie burn, something earlier GLP-1 medications couldn’t fully achieve