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Protective Role of Berberine and Coptischinensis Extract on T2MD Rats and Associated Islet Rin-5f Cells

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Decreased systolic blood pressure with CT-388 treatment was observed in cohorts 7 and 8 at week 4 (mean [SD] change from baseline day 29 of −9.3 [9.0] mmHg and −5.7 [18.3] mmHg, respectively, vs −0.3 [12.6] mmHg with placebo)