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In a once-daily multiple ascending dose phase Ib clinical trial and a 41-day phase IIa trial in overweight and type 2 diabetic patients, general safety and tolerability of MEDI0382 were established, as well as placebo-corrected efficacy in reducing fasting blood glucose (−1.7 mmol/L), post-prandial glucose excursions following a mixed meal test (−22.6% AUC 0–4 h ), body weight (−2.1 kg), and liver fat (−19.6%) [7]
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