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DPP-4 enzyme cleaves GLP-1 with a half-life of approximately 2 minutes, which is why early drug development focused on DPP-4 inhibitors and on engineering longer-lived GLP-1 analogs
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Eine verzögerte Magenentleerung durch GLP-1-Rezeptoragonisten kann die Resorptionsgeschwindigkeit oral applizierter Arzneimittel reduzieren
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