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The obesity drug semaglutide (Wegovy) conferred a significantly higher risk of ischemic optic neuropathy (ION) than any other GLP-1 agonist, including semaglutide for diabetes (Ozempic), an analysis of FDA data showed. Added

Interestingly, liraglutide’s effects on the gut microbial network were “weaker” than metformin’s, resulting in a post-treatment microbiota composition that more closely resembled that of healthy controls (suggesting a normalization of dysbiosis rather than a drastic reconfiguration) ( Another study of 52 subjects with T2D treated with GLP-1 RAs found that responders exhibited higher abundances of beneficial species such as Bacteroides dorei, Roseburia inulinivorans, Lachnoclostridium sp

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Key clinical wins : In 2024, Lilly announced new clinical trial results (e.g., further cardiovascular outcome benefits with tirzepatide), which have bolstered prescriber confidence

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