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In the absence of leptin, increased innervation of CRH neurons by PPG-derived axons were particularly pronounced, while there was no change in the density of PPG inputs onto Oxytocin neurons

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I spent months doing computational modeling [to design peptides with amino acid structures that would engage with the receptors] within a narrow category as I couldn’t choose a molecule that had previously been tested in a clinical context [because it could not then be legally marketed as a dietary supplement]