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17 Previously, we have shown, in mice fed high-fat-diet and supplemented with eriocitrin, a significant decrease in glucose and triacylglycerol and improvement of insulin sensitivity, associated with less oxidative stress and systemic inflammation, promoted by this citrus flavonoid
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The trial itself explicitly concluded that while the drug showed promise, further studies were necessary to establish whether setmelanotide could elicit clinically meaningful weight loss in a subset of the MC4R -deficient obese population
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