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PIONEER trial programme has showed around 70% of subjects had achieved their glycaemic target of HbA1c 9%.[23] Another post hoc analysis of PIONEER trials showed Asians were more respondent to semaglutide in terms of HbA1c reduction and weight reduction.[24] It is worth mentioning that in PIONEER 8 trial, most of the Asians (66) were Indians (51).[22] EARLY STAGE OF DIABETES PIONEER 1 has established the clinical efficacy of oral semaglutide as monotherapy and first-line drug after diet and exercise
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