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With GLP-1 receptor agonists (GLP-1 RAs) , we now have a tool that can accelerate weight loss and glycemic control more effectively than ever before — producing 5–18% body-weight reduction in clinical trials ( Endocrinology Advisor )
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In type 2 diabetes, the incretin effect is reduced, through a combination of GLP-1 deficiency and defective GLP-1 signalling, and possibly reduced islet responsiveness to GIP (Fig
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