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50 Gastrointestinal Motility Disorders: Gastric and Intestinal Manifestations GLP-1 RAs reduce GI motility and prolong intestinal transit time, effects that have raised concerns regarding an increased risk of gastroparesis, intestinal obstruction, or ileus
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[8] [9] This metabolic conflict could reduce the efficacy of tirzepatide, necessitating closer monitoring and potentially increasing the risk of hyperglycaemia
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