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Mechanistic and Translational Studies Preclinical research in rodent models has characterized the additive effects of amylin and GLP-1 receptor activation on hypothalamic appetite circuits, energy expenditure, and gastric emptying
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We assessed common measures of efficacy, such as change in HbA 1c and body weight, as well as additional endpoints that are clinically relevant but could not previously be indirectly assessed in other studies (eg, lipid parameters and eGFR) because of absence of available data
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