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GLP-1Rs are expressed in key reward-processing structures, including the VTA, NAc, lateral septum, hippocampus, and MHb

Diet and Sports Nutrition

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A simplified model looks like this: GLP-1 ↓ Helps reduce appetite and slows gastric emptying GIP ↓ Supports incretin signaling and metabolic regulation Glucagon ↓ May increase energy expenditure and fat oxidation ↓ Potential Combined Effect Reduced caloric intake Higher energy expenditure Improved metabolic control Greater body-weight reduction than incretin agonism alone (hypothesis under investigation) It is important to emphasize that this integrated mechanism remains an area of active research