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Discontinuation rates due to adverse events: Dysesthesia — the abnormal tingling sensation first flagged in TRIUMPH-4 — was reported in TRIUMPH-1 as well, though Lilly's top-line release described it as generally mild with most affected participants continuing treatment
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“If you tighten glycemic control very tightly very quickly, you can have a paradoxical effect where actually the eye disease gets worse for a period of time.” In other words, rather than being a secondary effect of the drug, the worsening of DR and maybe NAION could be secondary to what the drug does in the body