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When to call your provider about side effects Contact your provider within 24 hours if you experience any of the following on tirzepatide, whether you're on weekly or split dosing: Vomiting more than 3 times in 24 hours, or inability to keep down fluids Severe abdominal pain that doesn't resolve within 6 hours Signs of dehydration (dark urine, dizziness when standing, confusion, dry mouth despite drinking fluids) Symptoms suggesting pancreatitis (severe upper abdominal pain radiating to the back, nausea, fever) Symptoms suggesting gallbladder disease (right upper abdominal pain, especially after eating, nausea, yellowing of skin or eyes) Persistent diarrhea (more than 6 episodes in 24 hours) lasting longer than 48 hours Heart rate above 100 beats per minute at rest, or new palpitations Most GI side effects on tirzepatide are mild to moderate and resolve within 72 hours of each dose increase

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Withdrawal symptoms that feel unmanageable, like intense anxiety, vomiting, diarrhea, shaking, sweating, or overwhelming cravings

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