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and the biological pathways in which differential genes were involved included apoptotic process involved in development, extracellular structure organization, activation of MAPKK activity, apoptotic process involved in morphogenesis, positive regulation of coagulation, positive regulation of hemostasis, positive regulation of blood coagulation, regulation of apoptotic process involved in development, cell junction maintenance, and regulation of apoptotic process involved in morphogenesis
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•• The landmark SELECT trial demonstrated that semaglutide reduces major adverse cardiovascular events in patients with overweight or obesity without diabetes, supporting expanded use of GLP-1RAs beyond glycemic control
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