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Study Design: Participants who achieved average 20.9% weight loss on tirzepatide over 36 weeks were randomized to either: Continue tirzepatide Switch to placebo Results at 88 Weeks (52 weeks after randomization): Continued Tirzepatide: Additional 5.5% weight loss Total weight loss: 25.3% from baseline 89.5% maintained at least 80% of initial weight loss Switched to Placebo: 14% weight regain Total weight loss: 9.9% from baseline Only 16.6% maintained at least 80% of initial weight loss Key Takeaway: Continued treatment is essential for maintaining weight loss
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18 Type 2 diabetes mellitus Preclinical studies GLP-1RAs are associated with a modest reduction in blood pressure and a slight increase in heart rate, but no significant association with hypertension (93)
