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[link to: Retatrutide Weight-Loss Trial Data Explained] Type 2 diabetes findings The TRANSCEND-T2D-1 trial, a 40-week Phase 3 study in adults with type 2 diabetes inadequately controlled by diet and exercise, reported that retatrutide met the primary and all key secondary endpoints, delivering A1C reductions of up to 2.0% and average weight loss of up to 16.8% on the 12 mg dose

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The most observed adverse effect is intestinal nausea, which could be reduced by using low doses at the beginning of therapy [26]