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However, exposure to high glucose conditions did increase mRNA expression and membrane-bound DPP-4 activity in human glomerular (76) and dermal (77) microvascular endothelial cells in vitro , although, interestingly, not in macrovascular (human aortic) endothelial cells (77)
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Recent advancements in pharmacotherapy—particularly the development of hormone-based agents that modulate appetite and metabolism—have significantly improved weight loss outcomes
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