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However, when administered during reperfusion, both GLP-1 (7-36amide) and GLP-1 (9-36amide) improve functional recovery from I/R injury in both WT and GLP-1R KO mice [201]

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Strategic Implications If validated in prospective randomized trials, GLP-1 receptor agonists could: Represent an adjunctive strategy in obesity-associated asthma Expand the therapeutic footprint of GLP-1s beyond metabolic disease Influence treatment guidelines in high-BMI asthma populations Given the rapid adoption of GLP-1 therapies globally, further investigation into respiratory benefits could have significant clinical and commercial implications