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These studies revealed that tirzepatide is an imbalanced and biased dual GIP-R/GLP-1R co-agonist, which stimulates GIP receptors in a manner analogous to its parent peptide but favors cAMP generation over β-arrestin recruitment at the GLP-1R
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This information assists your physician in determining whether fatigue relates to the medication, requires dose adjustment, or necessitates further diagnostic evaluation
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