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For someone weighing 250 pounds, this translates to a loss of 37–55 pounds—a magnitude that significantly improves knee and back stress, cardiovascular risk, and blood pressure control

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For instance, two fibroblast growth factor (FGF)-21 analogues, pegozafermin and efruxifermin, have already shown promising results in MASH-related fibrosis and MASH resolution [104,105]