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To investigate the relative contribution of non-genetic factors that predict GLP1 medication efficacy, we fit a linear model to assess the combined effect of age, sex, pre-treatment BMI, drug type, drug dose and time on drug on total BMI loss (Supplementary Table 3)

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Initially developed for metabolic conditions such as type 2 diabetes and obesity, these agents have demonstrated the capacity to modulate reward-related behaviors across a diverse range of preclinical addiction models, including alcohol, nicotine, psychostimulants, and opioids