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Factors that may contribute to muscle loss during weight loss in general, or with Ozempic treatment include: Appetite loss Loss of interest in eating Calorie restriction Low protein intake Pre-existing low muscle mass Low physical activity History of “yoyo dieting” (weight cycling) Older age Frailty Type 2 diabetes Obesity occurring with type 2 diabetes or prediabetes may also be associated with lower muscle mass, and can lead to a more rapid decline in muscle mass in the older person
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