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drugs — disulfiram (makes you sick if you drink, so compliance is dismal), acamprosate (modest effect, three-times-daily dosing), and naltrexone (works for some, but adherence is poor)
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Furthermore, liraglutide pretreatment in human SH-SY5Y neuroblastoma cell culture protected against the apoptotic effects of okadaic acid and limited tau activation and BACE1 expression, and in a rat model of okadaic acid-induced AD, liraglutide improved rat memory function and cognition and reduced neuronal apoptosis, tau phosphorylation, and BACE1 levels (163)
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