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Additionally, the T149M variant is associated with increased T2D risk and has normal surface expression but reduced binding affinity for GLP-1 and Exenatide, as well as reduced cAMP production (Beinborn et al., 2005), although a study was able to rescue both cAMP and ERK1/2 signalling for this variant using the allosteric modulator Compound 2 (Koole et al., 2011)
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