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Personal or family history of medullary thyroid cancer, Multiple Endocrine Neoplasia syndrome type 2, history of severe pancreatitis, active gallbladder disease, pregnancy or plans to become pregnant, severe gastrointestinal disease
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Notably, although gallbladder disorders frequently manifest, advanced gastrointestinal complications such as intestinal obstruction and periprocedural aspiration, and emergent concerns regarding suicidality and ocular problems require further longitudinal studies to refine the usage guidelines for GLP-1 RAs in susceptible populations
