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subcutaneous sema semaglutide SGLT2i Sodium-glucose co-transporter-2 inhibitor sita sitagliptin SNAC Sodium N-(8-[2-hydroxybenzoyl]amino)caprylate SU Sulfonylurea t 1/2 Terminal half-life T2D Type 2 diabetes T max Time to maximum concentration Author contributions All authors contributed to the writing and critically edited each version of the manuscript

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The supernatant was collected, mixed with an equal amount of trichloroacetic acid, and incubated at room temperature for 1 h