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This effect of Poria cocos was due to a triterpenoid called Dehydrotrametanolic Acid which reduces the blood glucose level in diabetic mice (Sato et al
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In the “Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes” published in 2024, it was recommended to start GLP-1 RA ± sodium-glucose co-transporter 2 inhibitors (SGLT2i) in patients with T2DM and ASCVD, while also commenting upon noted benefit in specifically HFpEF as well [53]
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