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Investigation of the safety and efficacy profile of semaglutide and tirzepatide used in patients with T1D who have previously undergone allogeneic islet transplantation/pancreas transplantation and/or kidney transplantation for improving glucose control, reducing beta-cell glucotoxicity, mitigating the immunosuppressant-induced beta-cell dysfunction [152], preserving endogenous insulin secretion, preventing graft dysfunction and graft failure, promoting graft function and survival, and possibly reducing the required doses of immunosuppressants through anti-hyperglycemic actions and potential anti-inflammatory, antioxidant, immunomodulatory and beta-cell protective properties (stimulation of beta-cell proliferation and survival)
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No—stop what you are doing (sit or lie down immediately) but continue your medication unless your doctor advises otherwise
