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PIONEER 3 PIONEER 3 was a 78-week, multinational, randomized, double-blind trial that compared the long-term efficacy, safety, and tolerability of oral semaglutide 3, 7, or 14 mg with the dipeptidyl peptidase-4 inhibitor, sitagliptin, in 1864 patients (including 207 patients from Japan) with type 2 diabetes uncontrolled on metformin with or without a sulfonylurea [47]
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