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Additionally, the treatment was associated with decreased expression magnitudes of pro-inflammatory cytokines, including IL-17, IL-23, and TNF-α, in the affected skin tissue [201]

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An earlier 16-week Phase 1b trial in 45 Chinese participants reported "clinically meaningful" weight reduction and an A1c drop in the diabetes cohort, with mostly mild-to-moderate gastrointestinal side effects and no treatment-related discontinuations — the standard GLP-1 tolerability signature