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In mice lacking Glp1r in the Lck expression domain ( Glp1r Lck–/– ), Glp1r expression is abolished in multiple IEL subsets, including CD8αα + TCRαβ + and CD8αβ + TCRαβ + IELs, with an approximately 50% reduction observed in CD8αα + TCRγδ + IELs (34)

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Gastrointestinal changes are common