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Seek immediate medical care for: Severe, persistent upper abdominal pain (possible pancreatitis) Gallbladder symptoms: RUQ pain after meals Persistent vomiting or inability to keep fluids down Signs of dehydration or electrolyte imbalance Clinical Scenarios for Dosing Schedule Optimization Evaluating microdosing protocols: Assess how split dosing affects peak-to-trough variation compared to standard weekly administration