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For type 2 diabetes management , NICE guideline NG28 recommends GLP-1 receptor agonists as a treatment option when: Metformin and other oral medications have not achieved adequate glycaemic control The patient has a BMI of 35 kg/m² or higher (or lower thresholds for people from South Asian and related minority ethnic backgrounds) Weight loss would benefit other obesity-related comorbidities Continuation of GLP-1 therapy for diabetes typically requires demonstration of beneficial response, defined as a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at six months
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