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Synthesis of methacrylate-amidated hyaluronic acid (MeHA-NH 2 ) and Preparation of hydrogels The methacrylation of HA-NH₂ predominantly targets the primary amine groups (-NH₂) under mild alkaline conditions (pH 8.0), where their enhanced nucleophilicity favors the formation of methacrylamide linkages over potential esterification with the less reactive hydroxyl groups

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Freezing can damage the medication and make it ineffective