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In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea
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Elevated nighttime cortisol from HPA axis activation makes it harder to fall asleep and reduces time spent in deep, restorative sleep stages
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