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T2DM itself is known to disrupt the gut microbiome, often leading to reduced diversity and a decline in beneficial genera like Bifidobacterium, Bacteroides, and Faecalibacterium, with increases in potentially harmful genera such as Ruminococcus, Fusobacterium, and Blautia
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GLP-1RAs exert their effects by stimulating insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite through the activation of the GLP-1 receptor
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