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Metformin increases the body's own production of GLP-1, potentially mimicking some of the effects of GLP-1 receptor agonists
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Medication:Semaglutide (GLP-1)
Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks
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