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Besides, oxygen provision is deficient on account of hypertrophic adipose tissue and hypoxia is associated with fatty infiltration caused by M1 Mφ, which may be a potential mechanism of IR (122, 124)

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Receptor activation triggers an adenylyl-cyclase / cAMP / protein-kinase-A cascade with downstream effects on glucose-dependent insulin secretion, glucagon suppression, slowed gastric emptying, and central satiety signaling through hindbrain-to-hypothalamic projections