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Historically, the management of these conditions has emphasized lifestyle changes, including a reduced-calorie diet and increased physical activity, both of which are known to forestall or even reverse the development of T2DM and decrease the risk of cardiovascular disease
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Notably, in healthy human volunteers, acute administration of GLP-1, GLP-1 (9-36amide), or exenatide did not affect blood flow in the mesenteric or renal arteries, excluding splanchnic vasodilatation as a potential mechanism underlying the chronic hypotensive effect of GLP-1 [644]
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