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Mering and Minkowski's findings encouraged Gustave-Édouard Laguesse, a French histologist and pathologist, to theorise in 1893 that the pancreatic islets described by Langerhans produced an endocrine secretion (Hoet)
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While GIP indeed acts as an incretin in healthy individuals, researchers found an important limitation – in patients with type 2 diabetes, GIP loses most of its insulinotropic efficacy (the pancreatic cells become “GIP-resistant”) ( [32] )
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