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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with
In addition, subjects with bipolar syndromes and depression have found benefit from liraglutide treatment [92]
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Serum PE levels are decreased in patients with major depressive disorder vs
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