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Understanding how semaglutide interacts with your digestive system—and your individual genetic predispositions—helps you make an informed decision about whether GLP-1 therapy is right for you
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For astrocytes, GLP-1R activation prevents conversion to neurotoxic A1 phenotypes by interrupting microglia-derived IL-1α/TNF-α/C1q signaling [24,47,48], thereby promoting amyloid-β clearance in Alzheimer's disease models [48] and pathogenic α-synuclein in PD models [47]
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